Sepsis Startup Market Map 2025: 60+ Innovators Transforming Care Across 6 Frontlines

Sepsis is one of healthcare’s most urgent challenges — claiming 11 million lives each year worldwide. Early detection and treatment can save lives, but traditional systems are often too slow, too fragmented, or too late.

That’s why in 2025, startups across diagnostics, AI, devices, therapeutics, and monitoring are reshaping how we fight sepsis.

In this post, I’ve mapped 60+ sepsis-focused startups into 6 clear categories. Whether you’re a founder, investor, or health system leader, this will give you a clear view of where innovation is happening — and how you can plug into these solutions.

Why This Market Map Matters

• For hospitals & clinicians: See which innovations are reducing mortality, improving early detection, and aligning with sepsis bundles.

• For investors: Spot early-stage companies in diagnostics, AI, and biologics before they scale.

• For startups & researchers: Benchmark your solution and identify collaboration or funding opportunities.

• For payers & policymakers: Understand where value-based care and risk reduction can be accelerated.

At GrowthVybz, I’ve supported 500+ startups across 35 countries, and one pattern is clear: ecosystem visibility drives adoption, funding, and partnerships. This sepsis startup map is designed to provide exactly that.

The 6 Categories of Sepsis Innovation

1. Host Diagnostics

Startups leveraging immune-response biology and AI-driven rapid tests to catch sepsis earlier than cultures.

• Cytovale — 10-min ED immune activation test (cytovale.com)

• Immunexpress — SeptiCyte RAPID 1-hour host-response test (immunexpress.com)

• Inflammatix — TriVerity 29-gene host classifier (inflammatix.com)

• Prenosis — Sepsis ImmunoScore AI platform (prenosis.com)

• MeMed — 15-min bacterial vs viral host-protein test (me-med.com)

• Presymptom Health — AI sepsis ruling-out platform (presymptom.com)

• Abionic — CAPSULE PSP rapid bedside sepsis detection (abionic.com)

• SphingoTec — bio-ADM®/penKid® biomarkers for sepsis risk (sphingotec.com)

• Baebies — neonatal host-transcriptomic diagnostics (baebies.com)

• LoopDx — Spain-based lateral-flow early sepsis test (f6s.com/company/loopdx)

💡 Framework tie-in: These tools align with the “Rapid Host Response Detection” framework — shifting diagnostics from hours to minutes and enabling hospitals to hit the “golden hour” of sepsis intervention.

2. Pathogen ID

Culture-free pathogen detection & rapid antibiotic susceptibility testing (AST).

• T2 Biosystems — direct-from-blood pathogen ID (t2biosystems.com)

• Karius — cfDNA NGS microbial detection (kariusdx.com)

• Day Zero Diagnostics — direct-from-blood WGS & AST (dayzerodiagnostics.com)

• DeepUll — culture-free sepsis diagnostics (deepull.com)

• Selux Diagnostics — FDA-cleared phenotypic AST (seluxdx.com)

• Gradientech — QuickMIC® ultra-rapid AST (gradientech.se)

💡 System tie-in: These platforms operationalize the “Test-to-Treatment Continuum”, shrinking diagnosis-to-therapy cycles from 48 hours to just a few.

3. AI Support

AI-powered early-warning systems integrated into EHR/ICU workflows.

• Bayesian Health (TREWS) — real-time sepsis alerts (ventures.jhu.edu)

• Ambient Clinical Analytics — AWARE™ + Sepsis DART™ (ambientclinical.com)

• CLEW Medical — ICU deterioration monitoring (clewmed.com)

• Etiometry — ICU sepsis risk analytics (etiometry.com)

💡 Framework tie-in: These follow the “Predict, Alert, Act” system — embedding sepsis risk flags into hospital workflows to reduce delays and standardize care pathways.

4. Blood Devices

Extracorporeal devices removing pathogens, toxins, and inflammatory mediators.

• CytoSorbents — cytokine adsorption cartridge (cytosorbents.com)

• ExThera Medical — Seraph® 100 pathogen filter (extheramedical.com)

• MediSieve — magnetic blood filtration (medisieve.com)

• hemotune — nano-bead blood purification (hemotune.ch)

💡 System tie-in: Device-based startups align with the “Remove-to-Stabilize Model” — adjunct therapies to stabilize patients while antibiotics take effect.

5. Therapeutics

Drug and biologic startups tackling immune dysregulation and sepsis-associated organ failure.

• Inotrem — TREM-1 inhibitor (Phase 3) (inotrem.com)

• Adrenomed — anti-ADM therapy (adrenomed.com)

• AM-Pharma — ilofotase alfa for AKI in sepsis (am-pharma.com)

• InflaRx — anti-C5a antibody (inflarx.de)

• Enlivex — Allocetra™ macrophage cell therapy (enlivex.com)

💡 Framework tie-in: These companies apply “Precision Immunotherapy for Sepsis” — using biomarkers and immune modulation instead of one-size-fits-all antibiotics.

6. Monitoring

Wearables, remote systems, and neonatal-friendly tools for early deterioration detection.

• Isansys Lifecare — Patient Status Engine wearables (isansys.com)

• Caretaker Medical — wireless hemodynamics monitoring (caretakermedical.net)

• EarlySense — contact-free deterioration monitoring (hillrom.com)

• Baebies — pediatric-friendly microfluidic tests (baebies.com)

💡 System tie-in: These solutions fit into the “Continuous Surveillance Framework” — shifting sepsis detection from episodic labs to continuous real-time monitoring.

Key Frameworks for Hospitals & Startups

To help readers translate innovation into impact, here are 3 systems you can apply:

1. Sepsis Early Intervention Model (SEIM) → Combines host-response + AI alerts to cut time-to-antibiotics.

2. Test-to-Treatment Continuum → Integrates rapid ID + AST with pharmacy stewardship programs.

3. Remove-to-Stabilize Model → Deploys blood purification alongside antibiotics to prevent organ failure.

Hospitals can adopt these frameworks now. Startups can position their product inside one of these models to show alignment with clinical workflows.

Final Thoughts

Sepsis is no longer a “silent killer” hidden in ICUs. With 60+ startups across 6 innovation frontlines, the global ecosystem is moving toward faster diagnosis, AI-driven alerts, precision therapies, and real-time monitoring.

👉 If you’re a hospital leader, these solutions show how to save lives and cut costs.
👉 If you’re an investor, this is where the next wave of billion-dollar healthtech exits could emerge.
👉 If you’re a founder, this map shows where you can stand out — or partner up.

At GrowthVybz, I specialize in building market maps, ROI calculators, and digital growth systems for startups and investors. If you want your innovation or ecosystem mapped, showcased, and scaled — let’s connect.

📩 Contact me at GrowthVybz.com to feature your startup or commission a custom market map.